KMID : 0604520100360020105
|
|
Journal of the Society of Cosmetic Scientists of Korea 2010 Volume.36 No. 2 p.105 ~ p.113
|
|
Enhanced Transdermal Delivery of Drug Compounds Using Scalable and Deformable Ethosomes
|
|
An Eun-Jung
Choi Jang-Won Kim Jin-Woong Park Won-Seok Kim Han-Kon Park Ki-Dong Han Sung-Sik Shim Jong-Won
|
|
Abstract
|
|
|
This study introduces a flexible approach to enhance skin permeation by using ethosomes with deformable lipid membranes as well as controllable sizes. To demonstrate this, a set of ethosomes encapsulating an anti-hair loss ingredient, Triaminodil, as a model drug, were fabricated with varying their size, which was achieved by solely applying the different level of mechanical energy, while maintaining their chemical composition. After characterization of the ethosomes with dynamic light scattering, transmission electron microscopy, and deformability measurements, it was found that their membrane deformability depended on the particle size. Moreover, studies on in vitro skin permeation and murine anagen induction allowed us to figure out that the membrane deformability of ethosomes essentially affects delivery efficiency of Triaminodil through the skin. It was noticeable in our study that there existed an optimum particle size that can not only maximize the delivery of the drug through the skin, but also increase its actual dermatological activity. These findings offer a useful basis for understanding how ethosomes should be designed to improve delivery efficiency of encapsulated drugs therein in the aspects of changing their length scales and membrane properties.
|
|
KEYWORD
|
|
ethosomes, particle size, deformability, skin permeation, anti-hair loss ingredient
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|